7KHQ
Crystal structure of OXA-48 K73A in complex with meropenem
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Beta-lactamase | polymer | 244 | 28193.9 | 2 | UniProt (Q6XEC0) Pfam (PF00905) | Klebsiella pneumoniae | Oxacillinase-48, OXA-48 beta-lactamase |
| 2 | C, G (A, B) | (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid | non-polymer | 385.5 | 2 | Chemie (MER) | |||
| 3 | D, E, H, I (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | F, J (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A, B: 25 - 265 (UniProt: Q6XEC0)
| PDB | External Database | Details |
|---|---|---|
| Gly 22 | - | expression tag |
| His 23 | - | expression tag |
| Met 24 | - | expression tag |
| Ala 73 | Lys 73 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56387.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1043.6 | |
| All* | Total formula weight | 57431.5 |
