7KDO

Crystal structure of Escherichia coli HPPK in complex with bisubstrate inhibitor HP-73

Summary for 7KDO

Entry DOI	10.2210/pdb7kdo/pdb
Descriptor	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine (3 entities in total)
Functional Keywords	alpha beta, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Escherichia coli (strain K12)
Total number of polymer chains	1
Total formula weight	18639.25
Authors	Shaw, G.X.,Shi, G.,Ji, X. (deposition date: 2020-10-09, release date: 2020-12-02, Last modification date: 2023-10-18)
Primary citation	Shi, G.,Shaw, G.X.,Zhu, F.,Tarasov, S.G.,Ji, X. Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Transition state analogs for high affinity binding. Bioorg.Med.Chem., 29:115847-115847, 2021 Cited by PubMed: 33199204 DOI: 10.1016/j.bmc.2020.115847 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation