7KBH

Structure of Human HDAC2 in complex with a 2-substituted benzamide inhibitor (compound 16)

Summary for 7KBH

• Entry DOI: 10.2210/pdb7kbh/pdb
• Descriptor: Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: histone deacetylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 132416.05

Authors

Klein, D.J.,Liu, J. (deposition date: 2020-10-02, release date: 2020-12-30, Last modification date: 2024-03-06)

• Primary citation: Liu, J.,Yu, Y.,Kelly, J.,Sha, D.,Alhassan, A.B.,Yu, W.,Maletic, M.M.,Duffy, J.L.,Klein, D.J.,Holloway, M.K.,Carroll, S.,Howell, B.J.,Barnard, R.J.O.,Wolkenberg, S.,Kozlowski, J.A.; Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group.; Acs Med.Chem.Lett., 11:2476-2483, 2020; PubMed: 33335670; DOI: 10.1021/acsmedchemlett.0c00462

Experimental method

X-RAY DIFFRACTION (2.68 Å)