7KBH
Structure of Human HDAC2 in complex with a 2-substituted benzamide inhibitor (compound 16)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Histone deacetylase 2 | polymer | 377 | 43225.2 | 3 | UniProt (Q92769) Pfam (PF00850) | Homo sapiens (Human) | HD2 |
| 2 | D, K, Q (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E, F, L, M, R... (A, B, C) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 4 | G, H, I, N, O... (A, B, C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 6 | Chemie (PEG) | |||
| 5 | J, P, U (A, B, C) | N-{(1S)-5-{[2-(methylsulfanyl)benzene-1-carbonyl]amino}-1-[5-(naphthalen-2-yl)-1H-imidazol-2-yl]pentyl}-1,3-thiazole-5-carboxamide | non-polymer | 555.7 | 3 | Chemie (WB4) | |||
| 6 | V, W, X (A, B, C) | water | water | 18.0 | 528 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 377 (UniProt: Q92769)
| PDB | External Database | Details |
|---|---|---|
| Tyr 205 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 129675.5 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2740.6 | |
| All* | Total formula weight | 132416.0 |
