7KBH
Structure of Human HDAC2 in complex with a 2-substituted benzamide inhibitor (compound 16)
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q13547 |
| Chain | Residue | Details |
| A | HIS142 | |
| B | HIS142 | |
| C | HIS142 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37137925, ECO:0007744|PDB:8BPA, ECO:0007744|PDB:8BPB, ECO:0007744|PDB:8BPC |
| Chain | Residue | Details |
| A | ASP175 | |
| A | PHE188 | |
| A | THR191 | |
| A | VAL194 | |
| A | SER198 | |
| A | PHE199 | |
| A | ASP266 | |
| B | ASP175 | |
| B | ASP177 | |
| B | HIS179 | |
| B | PHE188 | |
| B | THR191 | |
| B | VAL194 | |
| B | SER198 | |
| B | PHE199 | |
| B | ASP266 | |
| C | ASP175 | |
| C | ASP177 | |
| C | HIS179 | |
| C | PHE188 | |
| C | THR191 | |
| C | VAL194 | |
| C | SER198 | |
| C | PHE199 | |
| C | ASP266 | |
| A | ASP177 | |
| A | HIS179 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37137925, ECO:0007744|PDB:8BPB, ECO:0007744|PDB:8BPC |
| Chain | Residue | Details |
| A | TYR224 | |
| B | TYR224 | |
| C | TYR224 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q13547 |
| Chain | Residue | Details |
| A | LYS75 | |
| B | LYS75 | |
| C | LYS75 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q13547 |
| Chain | Residue | Details |
| B | LYS222 | |
| A | LYS222 | |
| C | LYS222 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P70288 |
| Chain | Residue | Details |
| A | CYS263 | |
| A | CYS275 | |
| B | CYS263 | |
| B | CYS275 | |
| C | CYS263 | |
| C | CYS275 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS75 | |
| B | LYS75 | |
| C | LYS75 |
