7KAA
NMR solution structures of tirasemtiv drug bound to a fast skeletal troponin C-troponin I complex
Summary for 7KAA
Entry DOI | 10.2210/pdb7kaa/pdb |
NMR Information | BMRB: 30801 |
Descriptor | Troponin C, skeletal muscle,Troponin I, fast skeletal muscle chimera, CALCIUM ION, 6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol (3 entities in total) |
Functional Keywords | activator, contractile protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 17366.98 |
Authors | Mercier, P.,Li, M.X.,Hartman, J.J.,Sykes, B.D. (deposition date: 2020-09-30, release date: 2021-03-24, Last modification date: 2024-05-15) |
Primary citation | Li, M.X.,Mercier, P.,Hartman, J.J.,Sykes, B.D. Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle. J.Med.Chem., 64:3026-3034, 2021 Cited by PubMed: 33703886DOI: 10.1021/acs.jmedchem.0c01412 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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