7K4E
Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 30
Summary for 7K4E
Entry DOI | 10.2210/pdb7k4e/pdb |
Related | 7K4A 7K4B 7K4C 7K4D |
EMDB information | 22662 22663 22664 22665 22666 |
Descriptor | Transient receptor potential cation channel subfamily V member 6, 5-({4-[(1R,4S)-3'-methyl[1,2,3,4-tetrahydro[1,1'-biphenyl]]-4-yl]piperazin-1-yl}methyl)pyridin-2(1H)-one (2 entities in total) |
Functional Keywords | trpv6, ion channel, inhibitor, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 309904.70 |
Authors | Neuberger, A.,Nadezhdin, K.D.,Singh, A.K.,Sobolevsky, A.I. (deposition date: 2020-09-15, release date: 2020-12-09, Last modification date: 2024-03-06) |
Primary citation | Bhardwaj, R.,Lindinger, S.,Neuberger, A.,Nadezhdin, K.D.,Singh, A.K.,Cunha, M.R.,Derler, I.,Gyimesi, G.,Reymond, J.L.,Hediger, M.A.,Romanin, C.,Sobolevsky, A.I. Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6:-, 2020 Cited by PubMed: 33246965DOI: 10.1126/sciadv.abe1508 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.34 Å) |
Structure validation
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