7K4E
Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 30
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Transient receptor potential cation channel subfamily V member 6 | polymer | 670 | 77021.8 | 4 | UniProt (Q9H1D0) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) In PDB | Homo sapiens (Human) | TrpV6,CaT-like,CaT-L,Calcium transport protein 1,CaT1,Epithelial calcium channel 2,ECaC2 |
2 | A, B, C, D | 5-({4-[(1R,4S)-3'-methyl[1,2,3,4-tetrahydro[1,1'-biphenyl]]-4-yl]piperazin-1-yl}methyl)pyridin-2(1H)-one | non-polymer | 363.5 | 5 | Chemie (VUJ) |
Sequence modifications
A, B, C, D: 1 - 667 (UniProt: Q9H1D0)
PDB | External Database | Details |
---|---|---|
Val 668 | - | expression tag |
Pro 669 | - | expression tag |
Arg 670 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 308087.2 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1817.5 | |
All* | Total formula weight | 309904.7 |