7K48

Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV

7K48 の概要

• エントリーDOI: 10.2210/pdb7k48/pdb
• EMDBエントリー: 22661
• 分子名称: Maltose/maltodextrin-binding periplasmic protein,Ion transport protein,Sodium channel protein type 9 subunit alpha chimera, Mu-theraphotoxin-Hs2a (2 entities in total)
• 機能のキーワード: ion channel, voltage-gated sodium channel, gating-modifier toxin, membrane protein
• 由来する生物種: Escherichia coli (strain K12); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 290075.36

構造登録者

Wisedchaisri, G.,Tonggu, L.,Gamal El-Din, T.M.,McCord, E.,Zheng, N.,Catterall, W.A. (登録日: 2020-09-15, 公開日: 2020-12-02, 最終更新日: 2021-01-20)

• 主引用文献: Wisedchaisri, G.,Tonggu, L.,Gamal El-Din, T.M.,McCord, E.,Zheng, N.,Catterall, W.A.; Structural Basis for High-Affinity Trapping of the Na V 1.7 Channel in Its Resting State by Tarantula Toxin.; Mol.Cell, 81:38-48.e4, 2021; PubMed: 33232657; DOI: 10.1016/j.molcel.2020.10.039

実験手法

ELECTRON MICROSCOPY (3.6 Å)