7K2U
DHODH IN COMPLEX WITH LIGAND 13
Summary for 7K2U
Entry DOI | 10.2210/pdb7k2u/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (9 entities in total) |
Functional Keywords | dihydroorotate dehydrogenase, dhodh, oxidoreductase, inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41956.30 |
Authors | Shaffer, P.L. (deposition date: 2020-09-09, release date: 2020-10-21, Last modification date: 2024-03-06) |
Primary citation | DeRatt, L.G.,Christine Pietsch, E.,Tanner, A.,Shaffer, P.,Jacoby, E.,Wang, W.,Kazmi, F.,Zhang, X.,Attar, R.M.,Edwards, J.P.,Kuduk, S.D. A carboxylic acid isostere screen of the DHODH inhibitor Brequinar. Bioorg.Med.Chem.Lett., 30:127589-127589, 2020 Cited by PubMed: 33007394DOI: 10.1016/j.bmcl.2020.127589 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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