7K2U

DHODH IN COMPLEX WITH LIGAND 13

Summary for 7K2U

Entry DOI	10.2210/pdb7k2u/pdb
Descriptor	Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (9 entities in total)
Functional Keywords	dihydroorotate dehydrogenase, dhodh, oxidoreductase, inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41956.30
Authors	Shaffer, P.L. (deposition date: 2020-09-09, release date: 2020-10-21, Last modification date: 2024-03-06)
Primary citation	DeRatt, L.G.,Christine Pietsch, E.,Tanner, A.,Shaffer, P.,Jacoby, E.,Wang, W.,Kazmi, F.,Zhang, X.,Attar, R.M.,Edwards, J.P.,Kuduk, S.D. A carboxylic acid isostere screen of the DHODH inhibitor Brequinar. Bioorg.Med.Chem.Lett., 30:127589-127589, 2020 Cited by PubMed: 33007394 DOI: 10.1016/j.bmcl.2020.127589 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation