7JZ0

Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1) and S-Adenosyl-L-homocysteine (SAH).

7JZ0 の概要

• エントリーDOI: 10.2210/pdb7jz0/pdb
• 分子名称: 2'-O-methyltransferase, Non-structural protein 10, RNA (5'-D(*(M7G))-R(P*(A2M)P*UP*U)-3'), ... (9 entities in total)
• 機能のキーワード: structural genomics, center for structural genomics of infectious diseases, csgid, nsp16, nsp10, complex, viral protein, sah, cap-1, viral protein-rna complex, viral protein/rna
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 103536.76

構造登録者

Minasov, G.,Shuvalova, L.,Rosas-Lemus, M.,Kiryukhina, O.,Brunzelle, J.S.,Satchell, K.J.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2020-09-01, 公開日: 2020-09-16, 最終更新日: 2024-03-06)

• 主引用文献: Rosas-Lemus, M.,Minasov, G.,Shuvalova, L.,Inniss, N.,Kiryukhina, O.,Brunzelle, J.,Satchell, K.J.F.; Structure of SARS-CoV-2 2'-O-methyltransferase heterodimer with RNA Cap analog and sulfates bound reveals new strategies for structure-based inhibitor design; Biorxiv, 2020; DOI: 10.1101/2020.08.03.234716

実験手法

X-RAY DIFFRACTION (2.15 Å)