7JYY
Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA)pUpUpApApA (Cap-0) and S-Adenosylmethionine (SAM).
Summary for 7JYY
Entry DOI | 10.2210/pdb7jyy/pdb |
Descriptor | 2'-O-methyltransferase, Non-structural protein 10, RNA (5'-D(*(M7G))-R(P*AP*UP*UP*A)-3'), ... (10 entities in total) |
Functional Keywords | structural genomics, center for structural genomics of infectious diseases, csgid, nsp16, nsp10, complex, viral protein, sam, cap-0, viral protein-rna complex, viral protein/rna |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More |
Total number of polymer chains | 6 |
Total formula weight | 103303.63 |
Authors | Minasov, G.,Shuvalova, L.,Rosas-Lemus, M.,Kiryukhina, O.,Brunzelle, J.S.,Satchell, K.J.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2020-09-01, release date: 2020-09-16, Last modification date: 2024-03-06) |
Primary citation | Minasov, G.,Rosas-Lemus, M.,Shuvalova, L.,Inniss, N.L.,Brunzelle, J.S.,Daczkowski, C.M.,Hoover, P.,Mesecar, A.D.,Satchell, K.J.F. Mn 2+ coordinates Cap-0-RNA to align substrates for efficient 2'- O -methyl transfer by SARS-CoV-2 nsp16. Sci.Signal., 14:-, 2021 Cited by PubMed: 34131072DOI: 10.1126/scisignal.abh2071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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