7JYY

Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA)pUpUpApApA (Cap-0) and S-Adenosylmethionine (SAM).

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	2'-O-methyltransferase	polymer	300	33556.4	2	UniProt (P0DTD1) Pfam (PF06460)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	NSP16
2	B, D (B, D)	Non-structural protein 10	polymer	141	15004.1	2	UniProt (P0DTD1) Pfam (PF09401)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	NSP10
3	E, F (E, F)	RNA (5'-D(*(M7G))-R(P*AP*UP*UP*A)-3')	polymer	7	2324.4	2		Severe acute respiratory syndrome coronavirus 2
4	G, Q (A, C)	S-ADENOSYLMETHIONINE	non-polymer		398.4	2	Chemie (SAM)
5	H, R (A, C)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	I, S, T (A, C)	SODIUM ION	non-polymer		23.0	3	Chemie (NA)
7	J (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
8	K, L, M, N, U... (A, C)	FORMIC ACID	non-polymer		46.0	7	Chemie (FMT)
9	O, P, X, Y (B, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
10	AA, BA, CA, DA, EA... (B, C, D, E, F...)	water	water		18.0	520	Chemie (HOH)

Sequence modifications

A, C: 6799 - 7096 (UniProt: P0DTD1)

PDB	External Database	Details
Ser 6797	-	expression tag
Asn 6798	-	expression tag

B, D: 4254 - 4392 (UniProt: P0DTD1)

PDB	External Database	Details
Ser 4252	-	expression tag
Asn 4253	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	101769.9
Non-Polymers*	Number of molecules	19
	Total formula weight	1533.7
All*	Total formula weight	103303.6

*Water molecules are not included.