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7JWB

SARS CoV2 Spike ectodomain with engineered trimerized VH binder

Summary for 7JWB
Entry DOI10.2210/pdb7jwb/pdb
EMDB information22514
Descriptorautonomous human heavy chain variable domain, Spike glycoprotein (2 entities in total)
Functional Keywordsspike, vh, sars, cov2, viral protein-immune system complex, viral protein/immune system
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight445524.15
Authors
QCRG Structural Biology Consortium (deposition date: 2020-08-25, release date: 2020-10-07, Last modification date: 2020-12-30)
Primary citationBracken, C.J.,Lim, S.A.,Solomon, P.,Rettko, N.J.,Nguyen, D.P.,Zha, B.S.,Schaefer, K.,Byrnes, J.R.,Zhou, J.,Lui, I.,Liu, J.,Pance, K.,Zhou, X.X.,Leung, K.K.,Wells, J.A.
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2.
Nat.Chem.Biol., 17:113-121, 2021
Cited by
PubMed: 33082574
DOI: 10.1038/s41589-020-00679-1
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (6 Å)
Structure validation

217705

건을2024-03-27부터공개중

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