SARS CoV2 Spike ectodomain with engineered trimerized VH binder

Summary for 7JWB

EMDB information22514
Descriptorautonomous human heavy chain variable domain, Spike glycoprotein (2 entities in total)
Functional Keywordsspike, vh, sars, cov2, viral protein-immune system complex, viral protein/immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight445524.15
QCRG Structural Biology Consortium (deposition date: 2020-08-25, release date: 2020-10-07, Last modification date: 2020-10-14)
Primary citation
Bracken, C.J.,Lim, S.A.,Solomon, P.,Rettko, N.J.,Nguyen, D.P.,Zha, B.S.,Schaefer, K.,Byrnes, J.R.,Zhou, J.,Lui, I.,Liu, J.,Pance, K.,Zhou, X.X.,Leung, K.K.,Wells, J.A.
Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike.
Biorxiv, 2020
PubMed: 32817948 (PDB entries with the same primary citation)
DOI: 10.1101/2020.08.08.242511
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers1 0.2% 0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload
PDB entries from 2020-10-14