7JUR
Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib
Summary for 7JUR
Entry DOI | 10.2210/pdb7jur/pdb |
Related | 7JUQ 7JUS 7JUT 7JUU 7JUV 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1 |
Descriptor | Kinase suppressor of Ras 2, Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total) |
Functional Keywords | kinase, pseudokinase, drug target, cell signaling and cancer, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 84544.50 |
Authors | Khan, Z.M.,Dar, A.C. (deposition date: 2020-08-20, release date: 2020-09-30, Last modification date: 2023-10-18) |
Primary citation | Khan, Z.M.,Real, A.M.,Marsiglia, W.M.,Chow, A.,Duffy, M.E.,Yerabolu, J.R.,Scopton, A.P.,Dar, A.C. Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588:509-514, 2020 Cited by PubMed: 32927473DOI: 10.1038/s41586-020-2760-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.82 Å) |
Structure validation
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