7JUR

Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib

7JUR の概要

• エントリーDOI: 10.2210/pdb7jur/pdb
• 関連するPDBエントリー: 7JUQ 7JUS 7JUT 7JUU 7JUV 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1
• 分子名称: Kinase suppressor of Ras 2, Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total)
• 機能のキーワード: kinase, pseudokinase, drug target, cell signaling and cancer, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84544.50

構造登録者

Khan, Z.M.,Dar, A.C. (登録日: 2020-08-20, 公開日: 2020-09-30, 最終更新日: 2023-10-18)

• 主引用文献: Khan, Z.M.,Real, A.M.,Marsiglia, W.M.,Chow, A.,Duffy, M.E.,Yerabolu, J.R.,Scopton, A.P.,Dar, A.C.; Structural basis for the action of the drug trametinib at KSR-bound MEK.; Nature, 588:509-514, 2020; PubMed: 32927473; DOI: 10.1038/s41586-020-2760-4

実験手法

X-RAY DIFFRACTION (2.82 Å)