7JT6

Mycobacterium tuberculosis dethiobiotin synthetase in complex with Tetrazole 2

Summary for 7JT6

• Entry DOI: 10.2210/pdb7jt6/pdb
• Related: 6NLZ 6NMZ 6NNZ 6NU6 6NVC 6NVE 6NVF 6NWG 7JT5
• Descriptor: ATP-dependent dethiobiotin synthetase BioD, {(1S,2R)-2-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]cyclopentyl}acetic acid, GLYCEROL, ... (5 entities in total)
• Functional Keywords: inhibitor, ligase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 4
• Total formula weight: 95672.91

Authors

Pederick, J.P.,Bean, J.H.,Bruning, J.B. (deposition date: 2020-08-17, release date: 2021-09-08, Last modification date: 2023-10-18)

• Primary citation: Schumann, N.C.,Lee, K.J.,Thompson, A.P.,Salaemae, W.,Pederick, J.L.,Avery, T.,Gaiser, B.I.,Hodgkinson-Bean, J.,Booker, G.W.,Polyak, S.W.,Bruning, J.B.,Wegener, K.L.,Abell, A.D.; Inhibition of Mycobacterium tuberculosis Dethiobiotin Synthase ( Mt DTBS): Toward Next-Generation Antituberculosis Agents.; Acs Chem.Biol., 16:2339-2347, 2021; PubMed: 34533923; DOI: 10.1021/acschembio.1c00491

Experimental method

X-RAY DIFFRACTION (2 Å)