7JSE

Adeno-Associated Virus Origin Binding Domain in complex with ssDNA

Summary for 7JSE

• Entry DOI: 10.2210/pdb7jse/pdb
• EMDB information: 22451
• Descriptor: Protein Rep68, DNA (5'-D(*TP*TP*TP*T)-3') (2 entities in total)
• Functional Keywords: aav, protein-dna, aaa+, sf3, huh, viral protein, viral protein-dna complex, viral protein/dna
• Biological source: Adeno-associated virus - 2 (AAV-2); More
• Total number of polymer chains: 24
• Total formula weight: 984459.14

Authors

Escalante, C.R. (deposition date: 2020-08-14, release date: 2020-12-09, Last modification date: 2024-05-29)

• Primary citation: Santosh, V.,Musayev, F.N.,Jaiswal, R.,Zarate-Perez, F.,Vandewinkel, B.,Dierckx, C.,Endicott, M.,Sharifi, K.,Dryden, K.,Henckaerts, E.,Escalante, C.R.; The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states.; Nucleic Acids Res., 48:12983-12999, 2020; PubMed: 33270897; DOI: 10.1093/nar/gkaa1133

Experimental method

ELECTRON MICROSCOPY (4.6 Å)