7JSE

Adeno-Associated Virus Origin Binding Domain in complex with ssDNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004519	molecular_function	endonuclease activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
A	0016887	molecular_function	ATP hydrolysis activity
A	0019079	biological_process	viral genome replication
A	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
A	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
A	0039693	biological_process	viral DNA genome replication
A	0042025	cellular_component	host cell nucleus
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding
A	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
B	0003677	molecular_function	DNA binding
B	0004519	molecular_function	endonuclease activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0006260	biological_process	DNA replication
B	0016887	molecular_function	ATP hydrolysis activity
B	0019079	biological_process	viral genome replication
B	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
B	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
B	0039693	biological_process	viral DNA genome replication
B	0042025	cellular_component	host cell nucleus
B	0046718	biological_process	symbiont entry into host cell
B	0046872	molecular_function	metal ion binding
B	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
C	0003677	molecular_function	DNA binding
C	0004519	molecular_function	endonuclease activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0006260	biological_process	DNA replication
C	0016887	molecular_function	ATP hydrolysis activity
C	0019079	biological_process	viral genome replication
C	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
C	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
C	0039693	biological_process	viral DNA genome replication
C	0042025	cellular_component	host cell nucleus
C	0046718	biological_process	symbiont entry into host cell
C	0046872	molecular_function	metal ion binding
C	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
D	0003677	molecular_function	DNA binding
D	0004519	molecular_function	endonuclease activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0006260	biological_process	DNA replication
D	0016887	molecular_function	ATP hydrolysis activity
D	0019079	biological_process	viral genome replication
D	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
D	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
D	0039693	biological_process	viral DNA genome replication
D	0042025	cellular_component	host cell nucleus
D	0046718	biological_process	symbiont entry into host cell
D	0046872	molecular_function	metal ion binding
D	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
E	0003677	molecular_function	DNA binding
E	0004519	molecular_function	endonuclease activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0006260	biological_process	DNA replication
E	0016887	molecular_function	ATP hydrolysis activity
E	0019079	biological_process	viral genome replication
E	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
E	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
E	0039693	biological_process	viral DNA genome replication
E	0042025	cellular_component	host cell nucleus
E	0046718	biological_process	symbiont entry into host cell
E	0046872	molecular_function	metal ion binding
E	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
F	0003677	molecular_function	DNA binding
F	0004519	molecular_function	endonuclease activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0006260	biological_process	DNA replication
F	0016887	molecular_function	ATP hydrolysis activity
F	0019079	biological_process	viral genome replication
F	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
F	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
F	0039693	biological_process	viral DNA genome replication
F	0042025	cellular_component	host cell nucleus
F	0046718	biological_process	symbiont entry into host cell
F	0046872	molecular_function	metal ion binding
F	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
G	0003677	molecular_function	DNA binding
G	0004519	molecular_function	endonuclease activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0006260	biological_process	DNA replication
G	0016887	molecular_function	ATP hydrolysis activity
G	0019079	biological_process	viral genome replication
G	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
G	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
G	0039693	biological_process	viral DNA genome replication
G	0042025	cellular_component	host cell nucleus
G	0046718	biological_process	symbiont entry into host cell
G	0046872	molecular_function	metal ion binding
G	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
H	0003677	molecular_function	DNA binding
H	0004519	molecular_function	endonuclease activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0006260	biological_process	DNA replication
H	0016887	molecular_function	ATP hydrolysis activity
H	0019079	biological_process	viral genome replication
H	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
H	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
H	0039693	biological_process	viral DNA genome replication
H	0042025	cellular_component	host cell nucleus
H	0046718	biological_process	symbiont entry into host cell
H	0046872	molecular_function	metal ion binding
H	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
I	0003677	molecular_function	DNA binding
I	0004519	molecular_function	endonuclease activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0006260	biological_process	DNA replication
I	0016887	molecular_function	ATP hydrolysis activity
I	0019079	biological_process	viral genome replication
I	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
I	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
I	0039693	biological_process	viral DNA genome replication
I	0042025	cellular_component	host cell nucleus
I	0046718	biological_process	symbiont entry into host cell
I	0046872	molecular_function	metal ion binding
I	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
J	0003677	molecular_function	DNA binding
J	0004519	molecular_function	endonuclease activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0006260	biological_process	DNA replication
J	0016887	molecular_function	ATP hydrolysis activity
J	0019079	biological_process	viral genome replication
J	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
J	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
J	0039693	biological_process	viral DNA genome replication
J	0042025	cellular_component	host cell nucleus
J	0046718	biological_process	symbiont entry into host cell
J	0046872	molecular_function	metal ion binding
J	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
K	0003677	molecular_function	DNA binding
K	0004519	molecular_function	endonuclease activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0006260	biological_process	DNA replication
K	0016887	molecular_function	ATP hydrolysis activity
K	0019079	biological_process	viral genome replication
K	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
K	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
K	0039693	biological_process	viral DNA genome replication
K	0042025	cellular_component	host cell nucleus
K	0046718	biological_process	symbiont entry into host cell
K	0046872	molecular_function	metal ion binding
K	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
L	0003677	molecular_function	DNA binding
L	0004519	molecular_function	endonuclease activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0006260	biological_process	DNA replication
L	0016887	molecular_function	ATP hydrolysis activity
L	0019079	biological_process	viral genome replication
L	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
L	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
L	0039693	biological_process	viral DNA genome replication
L	0042025	cellular_component	host cell nucleus
L	0046718	biological_process	symbiont entry into host cell
L	0046872	molecular_function	metal ion binding
L	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
M	0003677	molecular_function	DNA binding
M	0004519	molecular_function	endonuclease activity
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0006260	biological_process	DNA replication
M	0016887	molecular_function	ATP hydrolysis activity
M	0019079	biological_process	viral genome replication
M	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
M	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
M	0039693	biological_process	viral DNA genome replication
M	0042025	cellular_component	host cell nucleus
M	0046718	biological_process	symbiont entry into host cell
M	0046872	molecular_function	metal ion binding
M	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
N	0003677	molecular_function	DNA binding
N	0004519	molecular_function	endonuclease activity
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0006260	biological_process	DNA replication
N	0016887	molecular_function	ATP hydrolysis activity
N	0019079	biological_process	viral genome replication
N	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
N	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
N	0039693	biological_process	viral DNA genome replication
N	0042025	cellular_component	host cell nucleus
N	0046718	biological_process	symbiont entry into host cell
N	0046872	molecular_function	metal ion binding
N	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
O	0003677	molecular_function	DNA binding
O	0004519	molecular_function	endonuclease activity
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0006260	biological_process	DNA replication
O	0016887	molecular_function	ATP hydrolysis activity
O	0019079	biological_process	viral genome replication
O	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
O	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
O	0039693	biological_process	viral DNA genome replication
O	0042025	cellular_component	host cell nucleus
O	0046718	biological_process	symbiont entry into host cell
O	0046872	molecular_function	metal ion binding
O	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
P	0003677	molecular_function	DNA binding
P	0004519	molecular_function	endonuclease activity
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0006260	biological_process	DNA replication
P	0016887	molecular_function	ATP hydrolysis activity
P	0019079	biological_process	viral genome replication
P	0039592	biological_process	symbiont-mediated arrest of host cell cycle during G2/M transition
P	0039645	biological_process	symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
P	0039693	biological_process	viral DNA genome replication
P	0042025	cellular_component	host cell nucleus
P	0046718	biological_process	symbiont entry into host cell
P	0046872	molecular_function	metal ion binding
P	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: For nuclease activity => ECO:0000255|PROSITE-ProRule:PRU01366

Chain	Residue	Details
A	TYR156
J	TYR156
K	TYR156
L	TYR156
M	TYR156
N	TYR156
O	TYR156
P	TYR156
B	TYR156
C	TYR156
D	TYR156
E	TYR156
F	TYR156
G	TYR156
H	TYR156
I	TYR156

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site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01366

Chain	Residue	Details
A	GLU83
D	GLU83
D	HIS90
D	HIS92
E	GLU83
E	HIS90
E	HIS92
F	GLU83
F	HIS90
F	HIS92
G	GLU83
A	HIS90
G	HIS90
G	HIS92
H	GLU83
H	HIS90
H	HIS92
I	GLU83
I	HIS90
I	HIS92
J	GLU83
J	HIS90
A	HIS92
J	HIS92
K	GLU83
K	HIS90
K	HIS92
L	GLU83
L	HIS90
L	HIS92
M	GLU83
M	HIS90
M	HIS92
B	GLU83
N	GLU83
N	HIS90
N	HIS92
O	GLU83
O	HIS90
O	HIS92
P	GLU83
P	HIS90
P	HIS92
B	HIS90
B	HIS92
C	GLU83
C	HIS90
C	HIS92

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00551

Chain	Residue	Details
A	GLY334
J	GLY334
K	GLY334
L	GLY334
M	GLY334
N	GLY334
O	GLY334
P	GLY334
B	GLY334
C	GLY334
D	GLY334
E	GLY334
F	GLY334
G	GLY334
H	GLY334
I	GLY334

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