Acyl-enzyme intermediate structure of SARS-CoV-2 Mpro in complex with its C-terminal autoprocessing sequence.

Summary for 7JOX

Descriptor3C-like proteinase, DIMETHYL SULFOXIDE (3 entities in total)
Functional Keywordsprotease, sars-cov-2, viral protein
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains2
Total molecular weight67885.49
Lee, J.,Worrall, L.J.,Paetzel, M.,Strynadka, N.C.J. (deposition date: 2020-08-07, release date: 2020-10-07)
Primary citation
Lee, J.,Worrall, L.J.,Vuckovic, M.,Rosell, F.I.,Gentile, F.,Ton, A.T.,Caveney, N.A.,Ban, F.,Cherkasov, A.,Paetzel, M.,Strynadka, N.C.J.
Crystallographic structure of wild-type SARS-CoV-2 Main Protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site
To Be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24840 5.9% 16.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-14