7KHP
Acyl-enzyme intermediate structure of SARS-CoV-2 Mpro in complex with its C-terminal autoprocessing sequence.
Replaces: 7JOXFunctional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 401 |
| Chain | Residue |
| A | PHE140 |
| A | LEU141 |
| A | ASN142 |
| A | SER144 |
| A | HIS163 |
| A | HIS172 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 402 |
| Chain | Residue |
| A | ARG298 |
| B | SER123 |
| A | MET6 |
| A | ALA7 |
| A | PHE8 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue DMS B 401 |
| Chain | Residue |
| A | SER123 |
| B | MET6 |
| B | ALA7 |
| B | PHE8 |
| B | GLN127 |
| B | ARG298 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291 |
| Chain | Residue | Details |
| A | HIS41 | |
| B | HIS41 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291 |
| Chain | Residue | Details |
| A | CYS145 | |
| B | CYS145 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| A | GLN306 | |
| B | GLN306 |
