7JOV
CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE 2 (ROCK2) IN COMPLEX WITH A PHENYLPYRAZOLE AMIDE INHIBITOR
Summary for 7JOV
Entry DOI | 10.2210/pdb7jov/pdb |
Descriptor | Rho-associated protein kinase 2, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-[(1S)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1H-pyrazol-4-yl)benzamide, ... (5 entities in total) |
Functional Keywords | rock1, kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 366400.97 |
Authors | Muckelbauer, J.K. (deposition date: 2020-08-07, release date: 2020-09-02, Last modification date: 2024-03-06) |
Primary citation | Hu, Z.,Wang, C.,Glunz, P.W.,Li, J.,Cheadle, N.L.,Chen, A.Y.,Chen, X.Q.,Myers, J.E.,Guarino, V.R.,Rose, A.,Sack, J.S.,Sitkoff, D.,Taylor, D.S.,Xu, S.,Yan, C.,Zhang, H.,Zhang, L.,Hennan, J.,Adam, L.P.,Wexler, R.R.,Quan, M.L. Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies. Bioorg.Med.Chem.Lett., 30:127495-127495, 2020 Cited by PubMed: 32798651DOI: 10.1016/j.bmcl.2020.127495 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.586 Å) |
Structure validation
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