7JOV
CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE 2 (ROCK2) IN COMPLEX WITH A PHENYLPYRAZOLE AMIDE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Rho-associated protein kinase 2 | polymer | 395 | 45400.6 | 8 | UniProt (O75116) Pfam (PF00069) | Homo sapiens (Human) | Rho kinase 2,Rho-associated,coiled-coil-containing protein kinase 2,coiled-coil-containing protein kinase II,ROCK-II,p164 ROCK-2 |
| 2 | I, Q (A, F) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 3 | J, K, M, O, P... (A, B, C, D, E...) | N-[(1S)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1H-pyrazol-4-yl)benzamide | non-polymer | 337.4 | 8 | Chemie (VFS) | |||
| 4 | L, N, S (B, C, F) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | AA, BA, CA, V, W... (F, G, H, A, B...) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 363205.2 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 3195.8 | |
| All* | Total formula weight | 366401.0 |
