7JNI

Crystal structure of the angiotensin II type 2 receptoror (AT2R) in complex with EMA401

7JNI の概要

• エントリーDOI: 10.2210/pdb7jni/pdb
• 分子名称: Soluble cytochrome b562,Type-2 angiotensin II receptor, Olodanrigan, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (7 entities in total)
• 機能のキーワード: angiotensin ii type 2 receptor, at2r, ema401, pd-126055, g protein-coupled receptor, gpcr, bril fusion, glioblastoma, gbm, membrane protein, lcp
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96734.20

構造登録者

Cherezov, V.,Shaye, H.,Han, G.W. (登録日: 2020-08-04, 公開日: 2022-02-09, 最終更新日: 2023-10-18)

• 主引用文献: Perryman, R.,Renziehausen, A.,Shaye, H.,Kostagianni, A.D.,Tsiailanis, A.D.,Thorne, T.,Chatziathanasiadou, M.V.,Sivolapenko, G.B.,El Mubarak, M.A.,Han, G.W.,Zarzycka, B.,Katritch, V.,Lebon, G.,Lo Nigro, C.,Lattanzio, L.,Morse, S.V.,Choi, J.J.,O'Neill, K.,Kanaki, Z.,Klinakis, A.,Crook, T.,Cherezov, V.,Tzakos, A.G.,Syed, N.; Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma.; Proc.Natl.Acad.Sci.USA, 119:e2116289119-e2116289119, 2022; PubMed: 35917342; DOI: 10.1073/pnas.2116289119

実験手法

X-RAY DIFFRACTION (3 Å)