7JMT

Crystal structure of schistosome BCL-2 bound to ABT-737

Summary for 7JMT

Entry DOI	10.2210/pdb7jmt/pdb
Descriptor	BCL-2 protein, 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE (3 entities in total)
Functional Keywords	apoptosis
Biological source	Schistosoma japonicum (Blood fluke)
Total number of polymer chains	6
Total formula weight	145380.47
Authors	Smith, N.A.,Smith, B.J.,Lee, E.F.,Colman, P.M.,Fairlie, W.D. (deposition date: 2020-08-02, release date: 2021-02-17, Last modification date: 2023-10-18)
Primary citation	Nguyen, W.,Lee, E.F.,Evangelista, M.,Lee, M.,Harris, T.J.,Colman, P.M.,Smith, N.A.,Williams, L.B.,Jarman, K.E.,Lowes, K.N.,Haeberli, C.,Keiser, J.,Smith, B.J.,Fairlie, W.D.,Sleebs, B.E. Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2. Acs Infect Dis., 7:1143-1163, 2021 Cited by PubMed: 33523649 DOI: 10.1021/acsinfecdis.0c00700 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation