7JMQ

The external aldimine form of the mutant beta-S377A Salmonella thypi tryptophan synthase in open conformation showing dual side chain conformations for the residue beta-Q114, sodium ion at the metal coordination site, and F9 inhibitor at the alpha-site. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring

Summary for 7JMQ

• Entry DOI: 10.2210/pdb7jmq/pdb
• Related: 6DZ4 6DZO 6WDU 6XSY
• Descriptor: Tryptophan synthase alpha chain, CHLORIDE ION, Tryptophan synthase beta chain, ... (11 entities in total)
• Functional Keywords: protein complex, lyase, f9f, internal aldimine
• Biological source: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720); More
• Total number of polymer chains: 2
• Total formula weight: 75512.08

Authors

Hilario, E.,Dunn, M.F.,Mueller, L.J. (deposition date: 2020-08-02, release date: 2021-08-04, Last modification date: 2023-10-18)

• Primary citation: Hilario, E.,Dunn, M.F.,Mueller, L.J.; The external aldimine form of mutant beta-S377A Salmonella thypi tryptophan synthase in open conformation showing dual side chain conformations for the residue beta-Q114, sodium ion at the metal coordination site, and F9 inhibitor at the alpha-site. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)