6WDU

The external aldimine form of the Salmonella thypi wild-type tryptophan synthase in open conformation showing multiple side chain conformations for the residue beta Q114 and sodium ion at the metal coordination site. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring.

Summary for 6WDU

• Entry DOI: 10.2210/pdb6wdu/pdb
• Related: 6dz4 6dzo
• Descriptor: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 1,2-ETHANEDIOL, ... (8 entities in total)
• Functional Keywords: lyase-inhibitor, protein complex, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720); More
• Total number of polymer chains: 2
• Total formula weight: 73800.52

Authors

Hilario, E.,Fan, L.,Dunn, M.F.,Mueller, L.J. (deposition date: 2020-04-01, release date: 2021-03-10, Last modification date: 2023-10-18)

• Primary citation: Hilario, E.,Fan, L.,Dunn, M.F.,Mueller, L.J.; The external aldimine form of the Salmonella thypi wild-type tryptophan synthase in open conformation showing multiple side chain conformations for the residue beta Q114 and sodium ion at the metal coordination site. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.4 Å)