7JMQ

The external aldimine form of the mutant beta-S377A Salmonella thypi tryptophan synthase in open conformation showing dual side chain conformations for the residue beta-Q114, sodium ion at the metal coordination site, and F9 inhibitor at the alpha-site. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring

7JMQ の概要

• エントリーDOI: 10.2210/pdb7jmq/pdb
• 関連するPDBエントリー: 6DZ4 6DZO 6WDU 6XSY
• 分子名称: Tryptophan synthase alpha chain, CHLORIDE ION, Tryptophan synthase beta chain, ... (11 entities in total)
• 機能のキーワード: protein complex, lyase, f9f, internal aldimine
• 由来する生物種: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75512.08

構造登録者

Hilario, E.,Dunn, M.F.,Mueller, L.J. (登録日: 2020-08-02, 公開日: 2021-08-04, 最終更新日: 2023-10-18)

• 主引用文献: Hilario, E.,Dunn, M.F.,Mueller, L.J.; The external aldimine form of mutant beta-S377A Salmonella thypi tryptophan synthase in open conformation showing dual side chain conformations for the residue beta-Q114, sodium ion at the metal coordination site, and F9 inhibitor at the alpha-site. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring.; To be Published,

実験手法

X-RAY DIFFRACTION (1.6 Å)