7JL3
Cryo-EM structure of RIG-I:dsRNA filament in complex with RIPLET PrySpry domain (trimer)
Summary for 7JL3
Entry DOI | 10.2210/pdb7jl3/pdb |
EMDB information | 22368 22369 22370 22371 |
Descriptor | Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, dsRNA strand1, ... (8 entities in total) |
Functional Keywords | innate immunity, e3 ligase, helicase, antiviral signaling, rlr, dsrna sensor, hydrolase-transferase-rna complex, hydrolase/transferase/rna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 340008.62 |
Authors | |
Primary citation | Kato, K.,Ahmad, S.,Zhu, Z.,Young, J.M.,Mu, X.,Park, S.,Malik, H.S.,Hur, S. Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. Mol.Cell, 81:599-613.e8, 2021 Cited by PubMed: 33373584DOI: 10.1016/j.molcel.2020.11.047 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.2 Å) |
Structure validation
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