7JKZ

Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with YF3-126

Summary for 7JKZ

• Entry DOI: 10.2210/pdb7jkz/pdb
• Descriptor: Bromodomain-containing protein 4, N-(1-[1,1-di(pyridin-2-yl)ethyl]-6-{1-methyl-6-oxo-5-[(piperidin-4-yl)amino]-1,6-dihydropyridin-3-yl}-1H-indol-4-yl)ethanesulfonamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: selective brd4-bd1 inhibitor, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15826.25

Authors

Ratia, K.M.,Xiong, R.,Li, Y.,Shen, Z.,Zhao, J.,Huang, F.,Dubrovyskyii, O.,Thatcher, G.R. (deposition date: 2020-07-29, release date: 2021-08-25, Last modification date: 2023-10-18)

• Primary citation: Li, Y.,Zhao, J.,Gutgesell, L.M.,Shen, Z.,Ratia, K.,Dye, K.,Dubrovskyi, O.,Zhao, H.,Huang, F.,Tonetti, D.A.,Thatcher, G.R.J.,Xiong, R.; Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.; J.Med.Chem., 63:7186-7210, 2020; PubMed: 32453591; DOI: 10.1021/acs.jmedchem.0c00456

Experimental method

X-RAY DIFFRACTION (2.49 Å)