7JHD

Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with TTC-352 and GRIP Peptide

7JHD の概要

• エントリーDOI: 10.2210/pdb7jhd/pdb
• 分子名称: Estrogen receptor, Nuclear receptor coactivator 2, 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-1-benzothiophene-6-ol, ... (4 entities in total)
• 機能のキーワード: breast cancer, synthetic agonist, drug resistance, apoptosis, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 61007.81

構造登録者

Fanning, S.W.,Abderraman, B.,Maximov, P.Y.,Jordan, V.C.,Greene, G.L. (登録日: 2020-07-20, 公開日: 2020-11-25, 最終更新日: 2023-10-18)

• 主引用文献: Abderrahman, B.,Maximov, P.Y.,Curpan, R.F.,Fanning, S.W.,Hanspal, J.S.,Fan, P.,Foulds, C.E.,Chen, Y.,Malovannaya, A.,Jain, A.,Xiong, R.,Greene, G.L.,Tonetti, D.A.,Thatcher, G.R.J.,Jordan, V.C.; Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer.; Mol.Cancer Ther., 20:11-25, 2021; PubMed: 33177154; DOI: 10.1158/1535-7163.MCT-20-0563

実験手法

X-RAY DIFFRACTION (2.402 Å)