7JFR

Auristatin bound to tubulin

Summary for 7JFR

• Entry DOI: 10.2210/pdb7jfr/pdb
• Related PRD ID: PRD_002435
• Descriptor: Tubulin alpha-1B chain, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Tubulin beta-2B chain, ... (11 entities in total)
• Functional Keywords: auristatin, tubulin, antimitotic, cell cycle
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 7
• Total formula weight: 261237.38

Authors

Moquist, P.N.,Waight, A. (deposition date: 2020-07-17, release date: 2020-09-16, Last modification date: 2023-11-15)

• Primary citation: Moquist, P.N.,Bovee, T.D.,Waight, A.B.,Mitchell, J.A.,Miyamoto, J.B.,Mason, M.L.,Emmerton, K.K.,Stevens, N.,Balasubramanian, C.,Simmons, J.K.,Lyon, R.P.,Senter, P.D.,Doronina, S.O.; Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models.; Mol.Cancer Ther., 20:320-328, 2021; PubMed: 33288628; DOI: 10.1158/1535-7163.MCT-20-0618

Experimental method

X-RAY DIFFRACTION (2.35 Å)