7HC7

PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodmain in complex with AVI-4051

This is a non-PDB format compatible entry.

Summary for 7HC7

• Entry DOI: 10.2210/pdb7hc7/pdb
• Group deposition: PanDDA analysis group deposition of SARS-CoV-2 NSP3 macrodomain ligand screen - analogues leading to AVI-4206 (G_1002300)
• Descriptor: Non-structural protein 3, N-cyclopropyl-N'-{4-[(2-oxopyrrolidin-1-yl)amino]-9H-pyrimido[4,5-b]indol-8-yl}urea, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: macrodomain, adp-ribose, sars-cov-2, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 2
• Total formula weight: 36758.37

Authors

Correy, G.J.,Fraser, J.S. (deposition date: 2024-08-01, release date: 2025-08-20)

• Primary citation: Correy, G.J.,Fraser, J.S.; Ligand screen against SARS-CoV-2 NSP3 macrodomain; To be published,

Experimental method

X-RAY DIFFRACTION (0.99 Å)