7FH2

Crystal structure of the first bromodomain of BRD4 in complex with 16D10

Summary for 7FH2

• Entry DOI: 10.2210/pdb7fh2/pdb
• Descriptor: Bromodomain-containing protein 4, N-[2-[2-[(E)-3-(2,5-dimethoxyphenyl)prop-2-enoyl]-4,5-dimethoxy-phenyl]ethyl]ethanamide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, bromodomain, brd4, histone, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 66437.92

Authors

Yokoyama, T.,Hirasawa, N. (deposition date: 2021-07-29, release date: 2022-08-03, Last modification date: 2023-11-29)

• Primary citation: Segawa, R.,Takeda, H.,Yokoyama, T.,Ishida, M.,Miyata, C.,Saito, T.,Ishihara, R.,Nakagita, T.,Sasano, Y.,Kanoh, N.,Iwabuchi, Y.,Mizuguchi, M.,Hiratsuka, M.,Hirasawa, N.; A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins.; Biochem Pharmacol, 194:114819-114819, 2021; PubMed: 34757034; DOI: 10.1016/j.bcp.2021.114819

Experimental method

X-RAY DIFFRACTION (2.492 Å)