7FH2

Crystal structure of the first bromodomain of BRD4 in complex with 16D10

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Bromodomain-containing protein 4	polymer	135	16160.6	4	UniProt (O60885) Pfam (PF00439) In PDB	Homo sapiens (Human)	Protein HUNK1
2	A, B, D	N-[2-[2-[(E)-3-(2,5-dimethoxyphenyl)prop-2-enoyl]-4,5-dimethoxy-phenyl]ethyl]ethanamide	non-polymer		413.5	4	Chemie (4JI)
3	A, B, C, D	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
4		water	water		18.0	42	Chemie (HOH)

Sequence modifications

A, B, C, D: 42 - 168 (UniProt: O60885)

PDB	External Database	Details
Met 34	-	initiating methionine
His 35	-	expression tag
His 36	-	expression tag
His 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
Met 41	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	64642.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1795.7
All*	Total formula weight	66437.9

*Water molecules are not included.