7FH0

Crystallographic structure of two neutralizing nanobodies in complex with SARS-CoV-2 spike receptor-binding Domain (RBD)

Summary for 7FH0

• Entry DOI: 10.2210/pdb7fh0/pdb
• Descriptor: Spike protein S1,Spike protein S1, nanobodies aRBD-2-7, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: sars-cov-2, rbd, spike, nanobodies, antiviral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 3
• Total formula weight: 106711.27

Authors

Zheng, P.,Jin, J. (deposition date: 2021-07-28, release date: 2022-08-03, Last modification date: 2023-11-29)

• Primary citation: Ma, H.,Zhang, X.,Zheng, P.,Dube, P.H.,Zeng, W.,Chen, S.,Cheng, Q.,Yang, Y.,Wu, Y.,Zhou, J.,Hu, X.,Xiang, Y.,Zhang, H.,Chiu, S.,Jin, T.; Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron.; Cell Res., 32:831-842, 2022; PubMed: 35906408; DOI: 10.1038/s41422-022-00700-3

Experimental method

X-RAY DIFFRACTION (3.2 Å)