7FGW

Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with pyrimethamine, NADPH and dUMP

7FGW の概要

• エントリーDOI: 10.2210/pdb7fgw/pdb
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, ... (6 entities in total)
• 機能のキーワード: pyrimethamine, toxoplasma gondii, dihydrofolate reductase, thymidylate synthase, oxidoreductase
• 由来する生物種: Toxoplasma gondii
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 280820.18

構造登録者

Vanichtanankul, J.,Yoomuang, A.,Taweechai, S.,Saeyang, T.,Yuvaniyama, Y.,Tarnchompoo, B.,Yuthavong, Y.,Kamchonwongpaisan, S. (登録日: 2021-07-28, 公開日: 2022-06-29, 最終更新日: 2023-11-29)

• 主引用文献: Vanichtanankul, J.,Yoomuang, A.,Taweechai, S.,Saeyang, T.,Pengon, J.,Yuvaniyama, J.,Tarnchompoo, B.,Yuthavong, Y.,Kamchonwongpaisan, S.; Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase.; Acs Chem.Biol., 17:1691-1702, 2022; PubMed: 35715223; DOI: 10.1021/acschembio.1c00627

実験手法

X-RAY DIFFRACTION (2.15 Å)