7FB7

Crystal structure of human UHRF1 TTD in complex with 5-amino-2,4-dimethylpyridine

7FB7 の概要

• エントリーDOI: 10.2210/pdb7fb7/pdb
• 分子名称: E3 ubiquitin-protein ligase UHRF1, (4S)-2-METHYL-2,4-PENTANEDIOL, 5-amino-2,4-dimethylpyridine, ... (6 entities in total)
• 機能のキーワード: dna methylation, histone modification, inhibitor, dna binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37546.07

構造登録者

Kori, S.,Arita, K.,Yoshimi, S. (登録日: 2021-07-08, 公開日: 2022-01-05, 最終更新日: 2023-11-29)

• 主引用文献: Kori, S.,Shibahashi, Y.,Ekimoto, T.,Nishiyama, A.,Yoshimi, S.,Yamaguchi, K.,Nagatoishi, S.,Ohta, M.,Tsumoto, K.,Nakanishi, M.,Defossez, P.A.,Ikeguchi, M.,Arita, K.; Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1.; Bioorg.Med.Chem., 52:116500-116500, 2021; PubMed: 34801826; DOI: 10.1016/j.bmc.2021.116500

実験手法

X-RAY DIFFRACTION (1.45 Å)