7F9N

Crystal structure of the variable region of Plasmodium RIFIN #4 (PF3D7_1000500) in complex with LAIR1

Summary for 7F9N

• Entry DOI: 10.2210/pdb7f9n/pdb
• Descriptor: Rifin, Leukocyte-associated immunoglobulin-like receptor 1 (2 entities in total)
• Functional Keywords: malaria, plasmodium falciparum, rifin, lair1, immune system
• Biological source: Plasmodium falciparum (isolate 3D7); More
• Total number of polymer chains: 4
• Total formula weight: 62674.67

Authors

Xie, Y.,Song, H.,Li, X.,Qi, J.,Gao, G.F. (deposition date: 2021-07-04, release date: 2021-08-18, Last modification date: 2024-10-16)

Primary citation

Xie, Y.,Li, X.,Chai, Y.,Song, H.,Qi, J.,Gao, G.F.
Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1.
Cell Rep, 36:109600-109600, 2021

PubMed Abstract: Malaria infection by Plasmodium falciparum continues to pose a global threat to the human population. P. falciparum expresses variable erythrocyte surface antigens such as RIFINs. Public antibodies with LAIR1 insertion have been identified from malarial patients against a subset of RIFINs. In this study, we solve a LAIR1-binding RIFIN structure: the complex structures of two RIFINs bound to mutated or wild-type LAIR1 in two distinct patterns. Notably, the two RIFINs engage similar binding sites on LAIR1 with different angles, and the RIFIN-binding sites overlap with the collagen-binding site. Surprisingly, RIFINs use completely different binding sites to bind to LAIR1 or LILRB1, indicating the kaleidoscopic change of RIFINs. We then verify that RIFIN could induce LAIR1-mediated cell signaling, and LAIR1-containing antibodies could block the pathway. The findings of this study provide structural insights into the mechanism of the immune escape of P. falciparum and the endless arms race between parasite and host.

PubMed: 34433057
DOI: 10.1016/j.celrep.2021.109600

Experimental method

X-RAY DIFFRACTION (3 Å)