7F3G

Crystal structure of DCLK1 kinase domain in complex with ruxolitinib

Summary for 7F3G

• Entry DOI: 10.2210/pdb7f3g/pdb
• Descriptor: Isoform 4 of Serine/threonine-protein kinase DCLK1, (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3 entities in total)
• Functional Keywords: doublecortin-like kinase 1, kinase domain, inhibitor, ruxolitinib, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 63556.71

Authors

Lim, H.J.,Jang, D.M.,Kim, H.S. (deposition date: 2021-06-16, release date: 2021-08-18, Last modification date: 2023-11-29)

• Primary citation: Jang, D.M.,Lim, H.J.,Hahn, H.,Lee, Y.,Kim, H.K.,Kim, H.S.; Structural Basis of Inhibition of DCLK1 by Ruxolitinib.; Int J Mol Sci, 22:-, 2021; PubMed: 34445192; DOI: 10.3390/ijms22168488

Experimental method

X-RAY DIFFRACTION (2.1 Å)