7F3G
Crystal structure of DCLK1 kinase domain in complex with ruxolitinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Isoform 4 of Serine/threonine-protein kinase DCLK1 | polymer | 282 | 31472.0 | 2 | UniProt (O15075) Pfam (PF00069) In PDB | Homo sapiens (Human) | Doublecortin domain-containing protein 3A,Doublecortin-like and CAM kinase-like 1,Doublecortin-like kinase 1 |
| 2 | A, B | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile | non-polymer | 306.4 | 2 | Chemie (RXT) | |||
| 3 | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A, B: 372 - 649 (UniProt: O15075)
| PDB | External Database | Details |
|---|---|---|
| Gly 368 | - | expression tag |
| Ala 369 | - | expression tag |
| Met 370 | - | expression tag |
| Gly 371 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62944.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 612.7 | |
| All* | Total formula weight | 63556.7 |
