7F3G

Crystal structure of DCLK1 kinase domain in complex with ruxolitinib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isoform 4 of Serine/threonine-protein kinase DCLK1	polymer	282	31472.0	2	UniProt (O15075) Pfam (PF00069)	Homo sapiens (Human)	Doublecortin domain-containing protein 3A,Doublecortin-like and CAM kinase-like 1,Doublecortin-like kinase 1
2	C, D (A, B)	(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile	non-polymer		306.4	2	Chemie (RXT)
3	E, F (A, B)	water	water		18.0	51	Chemie (HOH)

Sequence modifications

A, B: 372 - 649 (UniProt: O15075)

PDB	External Database	Details
Gly 368	-	expression tag
Ala 369	-	expression tag
Met 370	-	expression tag
Gly 371	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	62944.0
Non-Polymers*	Number of molecules	2
	Total formula weight	612.7
All*	Total formula weight	63556.7

*Water molecules are not included.