7F3G
Crystal structure of DCLK1 kinase domain in complex with ruxolitinib
Summary for 7F3G
Entry DOI | 10.2210/pdb7f3g/pdb |
Descriptor | Isoform 4 of Serine/threonine-protein kinase DCLK1, (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3 entities in total) |
Functional Keywords | doublecortin-like kinase 1, kinase domain, inhibitor, ruxolitinib, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 63556.71 |
Authors | Lim, H.J.,Jang, D.M.,Kim, H.S. (deposition date: 2021-06-16, release date: 2021-08-18, Last modification date: 2023-11-29) |
Primary citation | Jang, D.M.,Lim, H.J.,Hahn, H.,Lee, Y.,Kim, H.K.,Kim, H.S. Structural Basis of Inhibition of DCLK1 by Ruxolitinib. Int J Mol Sci, 22:-, 2021 Cited by PubMed: 34445192DOI: 10.3390/ijms22168488 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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