7F2M

Crystal structure of PDE4D catalytic domain complexed with compound 18d

Summary for 7F2M

• Entry DOI: 10.2210/pdb7f2m/pdb
• Descriptor: Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: pde4 inhibitor, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 117099.70

Authors

Huang, Y.-Y.,He, X.,Luo, H.-B. (deposition date: 2021-06-11, release date: 2021-10-20, Last modification date: 2023-11-29)

• Primary citation: Huang, Y.Y.,Deng, J.,Tian, Y.J.,Liang, J.,Xie, X.,Huang, Y.,Zhu, J.,Zhu, Z.,Zhou, Q.,He, X.,Luo, H.B.; Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.; J.Med.Chem., 64:13736-13751, 2021; PubMed: 34520193; DOI: 10.1021/acs.jmedchem.1c01085

Experimental method

X-RAY DIFFRACTION (2.20004160481 Å)