7F2M

Crystal structure of PDE4D catalytic domain complexed with compound 18d

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D	polymer	507	57859.5	2	UniProt (Q08499) Pfam (PF18100) Pfam (PF00233)	Homo sapiens (Human)	DPDE3,PDE43
2	C, F (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, G (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E, H (A, B)	(~{Z})-4-[9-[(4-fluorophenyl)methoxy]-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-6-oxidanylidene-pyrano[3,2-b]xanthen-5-yl]oxybut-2-enoic acid	non-polymer		600.6	2	Chemie (1GF)
5	I, J (A, B)	water	water		18.0	325	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	115719.0
Non-Polymers*	Number of molecules	6
	Total formula weight	1380.7
All*	Total formula weight	117099.7

*Water molecules are not included.