7EZW
Cyclic Peptide that Interacts with the eIF4E Capped-mRNA Binding Site
Summary for 7EZW
Entry DOI | 10.2210/pdb7ezw/pdb |
Descriptor | Eukaryotic translation initiation factor 4E, ALA-CYS-GLU-MET-GLY-PHE-PHE-GLN-ASP-CYS-GLY, SODIUM ION, ... (4 entities in total) |
Functional Keywords | ap dependent translation, rna binding protein-inhibitor complex, rna binding protein/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 26358.60 |
Authors | Brown, C.J.,Ng, S.,Frosi, Y. (deposition date: 2021-06-02, release date: 2022-06-08, Last modification date: 2023-11-29) |
Primary citation | Frosi, Y.,Ng, S.,Lin, Y.C.,Jiang, S.,Ramlan, S.R.,Lama, D.,Verma, C.S.,Asial, I.,Brown, C.J. Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE). Rsc Chem Biol, 3:916-930, 2022 Cited by PubMed: 35866173DOI: 10.1039/d2cb00099g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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