7EXC

Crystal structure of T2R-TTL-1129A2 complex

Summary for 7EXC

• Entry DOI: 10.2210/pdb7exc/pdb
• Descriptor: Tubulin alpha-1B chain, N-[[3-(1,3-benzodioxol-5-yloxy)phenyl]methyl]-9H-pyrido[3,4-b]indol-3-amine, GUANOSINE-5'-DIPHOSPHATE, ... (13 entities in total)
• Functional Keywords: tubulin, cancer, cell cycle-inhibitor complex, cell cycle
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 6
• Total formula weight: 270529.76

Authors

Yang, J.H.,Yan, W. (deposition date: 2021-05-26, release date: 2022-06-01, Last modification date: 2023-11-29)

• Primary citation: Li, Y.,Liu, Y.,Zhu, Z.,Yan, W.,Zhang, C.,Yang, Z.,Bai, P.,Tang, M.,Shi, M.,He, W.,Fu, S.,Liu, J.,Han, K.,Li, J.,Xie, L.,Ye, H.,Yang, J.,Chen, L.; Structure-Based Design and Synthesis of N-Substituted 3-Amino-beta-Carboline Derivatives as Potent alpha beta-Tubulin Degradation Agents; J.Med.Chem., 65:2675-2693, 2022; DOI: 10.1021/acs.jmedchem.1c02159

Experimental method

X-RAY DIFFRACTION (2.39 Å)