7EX8

Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 27

7EX8 の概要

• エントリーDOI: 10.2210/pdb7ex8/pdb
• 分子名称: Replicase, MANGANESE (II) ION, methyl (Z)-4-[1-[(3-chlorophenyl)methyl]-4-[(4-chlorophenyl)methyl]piperidin-4-yl]-2-oxidanyl-4-oxidanylidene-but-2-enoate, ... (5 entities in total)
• 機能のキーワード: endonuclease, hydrolase
• 由来する生物種: Abbey lake orthobunyavirus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25860.48

構造登録者

Kuang, W.,Hu, Z.,Gong, P. (登録日: 2021-05-26, 公開日: 2022-02-16, 最終更新日: 2023-11-29)

• 主引用文献: Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z.; Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ).; J.Virol., 96:e0217321-e0217321, 2022; PubMed: 35266805; DOI: 10.1128/jvi.02173-21

実験手法

X-RAY DIFFRACTION (1.97 Å)