7EX6
Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 11
Summary for 7EX6
Entry DOI | 10.2210/pdb7ex6/pdb |
Descriptor | Replicase, MANGANESE (II) ION, methyl (Z)-4-(4-(4-chlorobenzyl)-1-(2-methylbenzyl)piperidin-4-yl)-2-hydroxy-4-oxobut-2-enoate, ... (4 entities in total) |
Functional Keywords | endonuclease, hydrolase |
Biological source | Abbey lake orthobunyavirus |
Total number of polymer chains | 4 |
Total formula weight | 102934.79 |
Authors | |
Primary citation | Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z. Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ). J.Virol., 96:e0217321-e0217321, 2022 Cited by PubMed: 35266805DOI: 10.1128/jvi.02173-21 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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